Nature's Biological Response Modifiers In 1935 Decca Szent-Gyorgyl first described bioflavinoids when he found that an extract whom he called citrin which were made from le peels where more effective in preventing scurvy than vitamin C. This is so because of their ability to modify the immune system's reaction. Pulp and rind of citrus fruits, broccoli, eggplant, flaxseed, rose, hips, berries, whole grains, root vegetables and soybeans are also some of the. Foods that are rich in flavinoids include both green and black teas, red wine and dark chocolate. They are also now being currently researched for their role in preventing breast and colon cancers. They can strengthen the immune system and help it function properly. These flavinoids are known to reduce inflammation, oxidative stress, promote the healing of blood vessels and also repair skin damage.

In the following year, 1936 Szent-Gyorgyl then discovered that citrin contained a mixture of bioflavinoids, including hesperidine. Flavinoids are also referred to as "nature's biological response modifiers" or immunomodulators. These foods are rich in epicatechin and catechin bioflavinoids.

Bioflavinoids are plant chemicals that have potent antioxidant properties.