In the portie of milk thistle, the complementary nutrient is. Although such a dose would not be toxic, it could cause stomach upset or negative side effects. But, how much does it take to be effective for protecting and improving liver health and function.

Like many nutrients, silymarin has low "bioavailability". Bioavailability has to do with the body's ability to absorb a compound, a drug or nutrient. Researchers usually find ways to enhance and improve bioavailability.

Silymarin Dosage in Nutritional Supplements Any reasonable milk thistle or silymarin dose is safe. When taken orally, only a small portion of it may reach the bloodstream without being changed by the liver. When a drug or nutrient is injected, there is 100% bioavailability. Usually, the only thing that it takes is adding a complementary nutrient. Because it has low bioavailability, some manufacturers suggest a high silymarin dose. Researchers measure the amount that reaches the bloodstream unchanged, when it is taken orally.

For example, if a person suffers from hypoglycemia or low blood sugar, they should not take a large dosage, as the compound has been shown to lower blood sugar levels.